Sex-specific associations between surgery-induced weight loss and cancer outcomes: A post hoc analysis of the prospective, controlled Swedish Obese Subjects study
Bariatric surgery is associated with a lower risk of cancer and cancer-related mortality in women with obesity, with the strongest association observed for female-specific cancers in women with elevated baseline insulin levels. In men, bariatric surgery was not associated with overall cancer incidence or mortality. These findings support incorporating risk-based stratification to better tailor cancer prevention strategies in obesity care.
Authors
- Per Karlsson (ORCID: https://orcid.org/0000-0003-4841-2672)
- Markku Peltonen
- Johanna C. Andersson-Assarsson
- Björn Carlsson
- Lena M. S. Carlsson
- Peter Jacobson
- Cecilia Karlsson
- Sofie Ahlin
- Kajsa Sjöholm
- Felipe M. Kristensson
- Per-Arne Svensson
- Magdalena Taube
Institutions
- Sahlgrenska University Hospital (SE)
- Finnish Institute for Health and Welfare (FI)
- Region Västra Götaland (SE)
- NU Hospital Group (SE)
- AstraZeneca (Sweden) (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1371/journal.pmed.1004876
- Citations
- 1
- Primary Topic
- Bariatric Surgery and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 39.15
Funders
- Västra Götalandsregionen
- Kungl. Vetenskaps- och Vitterhets-Samhället i Göteborg
- Stiftelserna Wilhelm och Martina Lundgrens
- Vetenskapsrådet