Multi-Omics Analyses Unveil the Effects of a Long-Term High-Salt, High-Fat, and High-Fructose Diet on Rats

HSHFHFD-induced depletion of gut <i>Lactobacillus</i> spp. may disrupt the linoleic acid metabolic pathway and gut-brain axis homeostasis, leading to the impairment of neuroprotective function, blood-brain barrier dysfunction, and exacerbated neuroinflammation and oxidative stress in the brain. These effects potentially increase the susceptibility of rats to neurodegenerative disorders.

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Publication Details

Journal
Foods
Published
2026-01-04
DOI
https://doi.org/10.3390/foods15010171
Primary Topic
Diet, Metabolism, and Disease
Type
article
Field-Weighted Citation Impact
0.00

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article

Multi-Omics Analyses Unveil the Effects of a Long-Term High-Salt, High-Fat, and High-Fructose Diet on Rats

Yue Yao, Weiwei Su, Xiao Wu, Peibo Li et al.
Foods
Diet, Metabolism, and Disease
article

Multi-Omics Analyses Unveil the Effects of a Long-Term High-Salt, High-Fat, and High-Fructose Diet on Rats

Yue Yao, Weiwei Su, Xiao Wu, Peibo Li, Hao Wu
article en

Abstract

HSHFHFD-induced depletion of gut <i>Lactobacillus</i> spp. may disrupt the linoleic acid metabolic pathway and gut-brain axis homeostasis, leading to the impairment of neuroprotective function, blood-brain barrier dysfunction, and exacerbated neuroinflammation and oxidative stress in the brain. These effects potentially increase the susceptibility of rats to neurodegenerative disorders.

FoodsVol. 15(1)
Sun Yat-sen University (CN)
Sun Yat-sen University
Clean water and sanitation
Openalex Percentile: Top 98%
Diet, Metabolism, and Disease
DOIOpen Access PDFOpenAlex
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