Epcoritimab Combo Could Be New Standard for Some FLs

Patients with relapsed or refractory follicular lymphoma have few treatment options-with a rituximab-lenalidomide (R2) pairing considered the only alternative to immunochemotherapy. But data from the pivotal phase III EPCORE LF-1 trial show that a three-drug combination of epcoritimab plus R2 can reduce the risk of disease progression and death by 79% compared with R2 alone.

Publication Details

Journal
Cancer Discovery
Published
2025-12-31
DOI
https://doi.org/10.1158/2159-8290.cd-nw2025-0118
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
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Epcoritimab Combo Could Be New Standard for Some FLs

Cancer Discovery
Cancer Immunotherapy and Biomarkers
article

Epcoritimab Combo Could Be New Standard for Some FLs

article en

Abstract

Patients with relapsed or refractory follicular lymphoma have few treatment options-with a rituximab-lenalidomide (R2) pairing considered the only alternative to immunochemotherapy. But data from the pivotal phase III EPCORE LF-1 trial show that a three-drug combination of epcoritimab plus R2 can reduce the risk of disease progression and death by 79% compared with R2 alone.

Cancer DiscoveryVol. 16(2)
Good health and well-being
Openalex Percentile: Top 29%
Cancer Immunotherapy and Biomarkers
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Epcoritimab Combo Could Be New Standard for Some FLs · Cancer Discovery (2025) | TGRS Research Map | TGRS