Voriconazole-associated liver injury: clinical risk factor identification and predictive nomogram construction
Concomitant use of ezetimibe, caspofungin, glucocorticoids, and TC levels exceeding 4.485 mmol/L are independent risk factors for voriconazole-induced liver injury. The developed nomogram model offers clinically meaningful predictions for drug-induced liver injury risk, facilitating the optimization of voriconazole therapy safety.
Authors
- ShiJian Xiang
- Sheng Tang
- Shasha Li (ORCID: https://orcid.org/0000-0001-9177-8173)
- Dongge Feng
- Xiaoyi Liu
- Yiyi Ma
- Jinghao Wang
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fphar.2025.1688711
- Primary Topic
- Infections and bacterial resistance
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jinan University
- Guangzhou Municipal Science and Technology Bureau
- Guangzhou Municipal Science and Technology Project