Gamma secretase inhibitors, DAPT and MK0752, exhibit synergistic anticancer effects with cisplatin and docetaxel in 2D and 3D models of breast cancer
This study highlights the therapeutic potential of combining GSIs with standard chemotherapeutics to overcome drug resistance in breast cancer. The observed synergy and sequencing effects provide a strong basis for further mechanistic and translational investigations to optimize GSI-based combinational therapy strategies.
Authors
- Pádraig D’Arcy (ORCID: https://orcid.org/0000-0001-6671-7600)
- Johannes Gubat (ORCID: https://orcid.org/0000-0002-5645-3346)
- ÖZDEN YALÇIN ÖZUYSAL
- KÜBRA TELLİ
Institutions
- Linköping University (SE)
Publication Details
- Journal
- TURKISH JOURNAL OF BIOLOGY
- Published
- 2025-12-29
- DOI
- https://doi.org/10.55730/1300-0152.2776
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00