METTL16 Inhibits Lens Epithelial Cells Function in Diabetic Cataract via m <sup>6</sup> A-Modified DKK1-Mediated Wnt/β-Catenin Signaling

The METTL16-DKK1-Wnt/β-catenin axis inhibits the proliferation, migration, and cell-cycle progression of HG-induced HLECs. These findings provide an epigenetic insight into the pathogenesis of DC.

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Publication Details

Journal
Investigative Ophthalmology & Visual Science
Published
2026-01-05
DOI
https://doi.org/10.1167/iovs.67.1.1
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

METTL16 Inhibits Lens Epithelial Cells Function in Diabetic Cataract via m 6 A-Modified DKK1-Mediated Wnt/β-Catenin Signaling

Bei Zhang, Zhixuan Hu, Xue Wang, Xiaohui Jiang et al.
Investigative Ophthalmology & Visual Science
RNA modifications and cancer
article

METTL16 Inhibits Lens Epithelial Cells Function in Diabetic Cataract via m 6 A-Modified DKK1-Mediated Wnt/β-Catenin Signaling

Bei Zhang, Zhixuan Hu, Xue Wang, Xiaohui Jiang, Yun-e Zhao, Yahui Sun
article en

Abstract

The METTL16-DKK1-Wnt/β-catenin axis inhibits the proliferation, migration, and cell-cycle progression of HG-induced HLECs. These findings provide an epigenetic insight into the pathogenesis of DC.

Investigative Ophthalmology & Visual ScienceVol. 67(1)
Wenzhou Medical University (CN), Affiliated Eye Hospital of Wenzhou Medical College (CN)
Zero hunger
Openalex Percentile: Top 97%
RNA modifications and cancer
DOIOpen Access PDFOpenAlex
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