Impact of rituximab-based desensitization on T cell-mediated rejection in ABO-incompatible liver transplantation
Rituximab-based desensitization in ABO-I LT is associated with an increased incidence of early TCMR. Rituximab-induced B-cell depletion may promote T-cell activation through an IL-2-independent pathway, potentially contributing to increased TCMR.
Authors
- Kengo Sasaki (ORCID: https://orcid.org/0000-0002-3244-2845)
- Takashi Kamei (ORCID: https://orcid.org/0000-0003-1282-0463)
- Muneyuki Matsumura (ORCID: https://orcid.org/0000-0001-5921-2444)
- Naruhito Takido
- Yoshihiro Shono (ORCID: https://orcid.org/0000-0002-0804-285X)
- Atsushi Fujio (ORCID: https://orcid.org/0000-0002-2198-7508)
- Hiroyuki Ogasawara (ORCID: https://orcid.org/0000-0003-3213-3783)
- Michiaki Unno
- Kazuaki Tokodai
- Ryusuke Saito
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Surgery Today
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1007/s00595-025-03162-3
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00