Histone Lactylation–Mediated Metabolic Remodeling in Vascular Smooth Muscle Cells Aggravates Aortic Aneurysm and Dissection by Promoting Lactate Accumulation
Histone lactylation changes the metabolism and phenotype of VSMC in AAD. Inhibition of PDK1 or KAT7 may be a novel approach to treat or prevent AAD.
Authors
- Z H Dong
- Xi Sun (ORCID: https://orcid.org/0009-0004-7844-9753)
- Xiaoyi Zou (ORCID: https://orcid.org/0000-0001-5597-8848)
- Jiawei Gu
- Yikai Cui
- Wei Luo (ORCID: https://orcid.org/0000-0002-4317-636X)
- Liwei Liu (ORCID: https://orcid.org/0000-0002-4593-665X)
- Zhiqiang Pei
- Xingyu Weng
- Xuejuan Jin
- Xin Zhang (ORCID: https://orcid.org/0000-0002-1460-3676)
- Lihong Pan
- Tianyi Qiu
- Wenxuan Hong
- Ya Huang
- Junbo Ge
- Beijian Zhang
- Adilan Shalamu
- Aijun Sun
- Hao Lai
Institutions
- Fudan University (CN)
- National Health and Family Planning Commission (CN)
- Zhongshan Hospital (CN)
- Hi-Z Technology (United States) (US)
Publication Details
- Journal
- Circulation
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1161/circulationaha.125.072576
- Citations
- 3
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 92.78