Decoding the Mutational Hierarchy of Thyroid Cancer and Associated Signaling Pathways
The present study clarifies the mutation hierarchy and cooperative pathways in TC, underscoring the significance of BRAF- and RAS-driven oncogenesis. The discovery of under-explored genes within DNA damage response and cell cycle networks paves the way for targeted therapy development. Furthermore, the high frequency of TERT promoter mutations emphasizes their role in disease progression.
Authors
- Gowrang Kasaba Manjunath
- Muniasamy Neerathilingam (ORCID: https://orcid.org/0000-0002-4326-0385)
- Ankit Watts
- Disha Nashier
- Sumira Malik
- Chandan Goswami
- Tamoghna Mitra
- Abhishek Kumar
- Alisha Parveen
Institutions
- Chandigarh University (IN)
- National Institute of Science Education and Research (IN)
- Manipal Academy of Higher Education (IN)
- Institute of Bioinformatics (IN)
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Archives of Medical Research
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1016/j.arcmed.2025.103366
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00