Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.
We identified multiple sources of therapy-limiting side-effects of BAT in the swine model. These results will help guide the design of improved stimulation electrodes, surgical placement, and parameter programming to reduce BAT-associated side-effects while increasing on-target activation in patients.
Authors
- Nicole A. Pelot (ORCID: https://orcid.org/0000-0003-2844-0190)
- Bruce E. Knudsen (ORCID: https://orcid.org/0000-0003-0184-2050)
- Ashlesha Deshmukh (ORCID: https://orcid.org/0000-0003-3436-9087)
- Megan L. Settell (ORCID: https://orcid.org/0000-0002-2924-360X)
- Andrew J. Shoffstall (ORCID: https://orcid.org/0000-0002-0881-2180)
- Julie C. Savage (ORCID: https://orcid.org/0000-0002-0508-9468)
- Aaron J. Suminski (ORCID: https://orcid.org/0000-0002-8793-5049)
- Maria LaLuzerne
- Kevin Cheng (ORCID: https://orcid.org/0000-0002-8078-2158)
- Kip A. Ludwig
- Kathryn M Turk (ORCID: https://orcid.org/0000-0001-6776-5794)
- Constantinos Tsiptsis
- Roger J Schultz
- Kshirin Anand
- Annabelle B. Olson
- Warren Grill
- Ricardo Sanchez
Institutions
- University of Wisconsin–Madison (US)
- Duke University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-02
- DOI
- https://doi.org/10.64898/2026.01.02.697436
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Scheme for Promotion of Academic and Research Collaboration
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering