Allostatic load-cardiovascular disease associations and the mediating effect of inflammatory factors: a prospective cohort study
Elevated AL is linked to higher incident CVD with a non-linear exposure-response, and neutrophil-centric inflammation accounts for a measurable portion of the association. These findings support integrating stress-biology constructs and inflammatory profiling into cardiovascular risk assessment and prevention frameworks.
Authors
- Shuai Xu
- Yufeng Jiang
- Z. H. Li
- Teng Li
- Haonan Zhang (ORCID: https://orcid.org/0000-0002-3871-6819)
- Xufeng Huang
- Y L Xu
- Shiqian Zhang
- Xinyue Cui
- Chaoyang Yu
- Shujing Zhou
- Yahui Han
- Ge Zhang
- Ruhao Wu
Institutions
- University of Debrecen (HU)
- Harbin Medical University (CN)
- Soochow University (CN)
- Shanghai Ninth People's Hospital (CN)
- Beijing Hua Xin Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fcvm.2025.1724572
- Primary Topic
- Cardiac Health and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province