Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired pa
CR is a protective factor for cognition, and depressive symptoms act as a modifiable mediator. In AD patients with confirmed tau pathology, timely detection and management of depressive symptoms may help preserve cognition and enhance the benefits of CR.
Authors
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Nihong Chen
- Yucheng Gu
- Xiaoyuan Li
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fnagi.2025.1708268
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00