Photon FLASH spares radiation-induced changes in cardiac function, remodelling and arrythmia in a preclinical model
This study highlights the ability of photon FLASH to preserve cardiac function and structure from radiation damage with the level of sparing dependent on average dose rate and beam structure.
Authors
- Stephen J. McMahon (ORCID: https://orcid.org/0000-0001-5980-6728)
- Gabriel Adrian (ORCID: https://orcid.org/0000-0001-8837-4696)
- Mihaela Ghita (ORCID: https://orcid.org/0000-0002-2467-9156)
- Karl T. Butterworth (ORCID: https://orcid.org/0000-0001-7170-6789)
- Kathryn H. Brown (ORCID: https://orcid.org/0000-0003-0392-587X)
- Gerard Walls (ORCID: https://orcid.org/0000-0003-0845-9732)
- Kristoffer Petersson (ORCID: https://orcid.org/0000-0003-0300-5790)
- Ioannis I Verginadis
- Brianna N. Kerr
Institutions
- Queen's University Belfast (GB)
- Belfast Health and Social Care Trust (GB)
- Lund University (SE)
- University of Oxford (GB)
- CRUK/MRC Oxford Institute for Radiation Oncology (GB)
- The Northern Ireland Cancer Centre (GB)
- Skåne University Hospital (SE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1016/j.radonc.2026.111369
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council