GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model
Our findings demonstrate that TAU-induced pyroptosis contributes to neuroinflammation and synaptic dysfunction. While GSDMD inhibition mitigates inflammation, its absence exacerbates synaptic impairment, highlighting its complex role in tauopathies. Our results indicate that DMF treatment could offer a promising therapeutic avenue to modulate pyroptosis and neuroinflammation, and restore synaptic integrity in tauopathies.
Authors
- Ignacio Silva-Llanes (ORCID: https://orcid.org/0000-0003-3737-560X)
- David Sarrió (ORCID: https://orcid.org/0000-0003-4886-8290)
- Moreno‐Bueno Gema
- José Jiménez-Villegas (ORCID: https://orcid.org/0000-0003-3967-1832)
- Aaron Abdelkader-Guillén
- Lilia A. Smith
- Isabel Lastres-Becker
Institutions
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto de Investigaciones Biomédicas Sols-Morreale (ES)
- Hospital La Paz Institute for Health Research (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- MD Anderson Cancer Center Madrid (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s12929-025-01210-1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00