Intratumor heterogeneity score reveals immune landscape and survival stratification in colorectal cancer
This study introduces and validates a transcriptomic ITH score and a nine-gene ITRG-based prognostic model that delineate the immune landscape and enables effective survival stratification in CRC, complementing the limitations of current staging systems. Additionally, IL20RB is highlighted as a promising therapeutic target, supporting the development of personalized immuno-targeted combination therapies in CRC.
Authors
- Liyuan Ma
- H. Li
- Zijing Wang
- Jinzhong Cao
- Ruxue Ma
- Hengyi Lv
- Tao Jiang
- Xin Chang
- Zixin Zhang
- Xi Chen
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1671148
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00