When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds
This small descriptive series suggests that aSDH and SAH may differentially affect glymphatic and dural lymphatic functions. While glymphatic enrichment appeared only modestly altered after aSDH, it was severely impaired following SAH. In contrast, CSF clearance to blood was markedly reduced in the aSDH case, potentially reflecting compromised dural lymphatic drainage. The limited number of cases prevent broad generalization, but these findings offer novel hypothesis-generating observations that may inform future studies on the effects of surface intracranial hemorrhages on brain clearance pathways.
Authors
- Geir Ringstad (ORCID: https://orcid.org/0000-0003-0919-4510)
- Markus Hovd (ORCID: https://orcid.org/0000-0002-6077-0934)
- Are Hugo Pripp (ORCID: https://orcid.org/0000-0002-1678-7309)
- Lars Magnus Valnes (ORCID: https://orcid.org/0000-0001-9283-5563)
- Per Kristian Eide
Institutions
- Oslo University Hospital (NO)
- Statistics Norway (NO)
- OsloMet – Oslo Metropolitan University (NO)
- University of Oslo (NO)
- Sørlandet Hospital Arendal (NO)
Publication Details
- Journal
- Acta Neurochirurgica
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1007/s00701-025-06760-9
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 46.41