When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds

This small descriptive series suggests that aSDH and SAH may differentially affect glymphatic and dural lymphatic functions. While glymphatic enrichment appeared only modestly altered after aSDH, it was severely impaired following SAH. In contrast, CSF clearance to blood was markedly reduced in the aSDH case, potentially reflecting compromised dural lymphatic drainage. The limited number of cases prevent broad generalization, but these findings offer novel hypothesis-generating observations that may inform future studies on the effects of surface intracranial hemorrhages on brain clearance pathways.

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Publication Details

Journal
Acta Neurochirurgica
Published
2026-01-05
DOI
https://doi.org/10.1007/s00701-025-06760-9
Citations
2
Primary Topic
Cerebrospinal fluid and hydrocephalus
Type
article
Field-Weighted Citation Impact
46.41
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article

When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds

Geir Ringstad, Markus Hovd, Are Hugo Pripp, Lars Magnus Valnes et al.
2 citations
Acta Neurochirurgica
Cerebrospinal fluid and hydrocephalus
46.41
article

When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds

Geir Ringstad, Markus Hovd, Are Hugo Pripp, Lars Magnus Valnes, Per Kristian Eide
article en
2 citations

Abstract

This small descriptive series suggests that aSDH and SAH may differentially affect glymphatic and dural lymphatic functions. While glymphatic enrichment appeared only modestly altered after aSDH, it was severely impaired following SAH. In contrast, CSF clearance to blood was markedly reduced in the aSDH case, potentially reflecting compromised dural lymphatic drainage. The limited number of cases prevent broad generalization, but these findings offer novel hypothesis-generating observations that may inform future studies on the effects of surface intracranial hemorrhages on brain clearance pathways.

Acta NeurochirurgicaVol. 168(1)
Oslo University Hospital (NO), Statistics Norway (NO), OsloMet – Oslo Metropolitan University (NO), University of Oslo (NO), Sørlandet Hospital Arendal (NO)
Openalex Percentile: Top 1%
Cerebrospinal fluid and hydrocephalus
46.41
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When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds — Geir Ringstad, Markus Hovd, et al. · Acta Neurochirurgica (2026) | TGRS Research Map | TGRS