Mesenchymal stromal cells alleviate pulmonary arterial hypertension by suppressing pulmonary arterial adventitial fibroblast activation and extracellular matrix remodeling via the SOCS3/STAT3 pathway

Our findings underscore the importance of early intervention in the PAH disease course for MSC-based therapy. MSCs attenuate vascular remodeling and disease progression, possibly through the SOCS3/STAT3 signaling pathway, by targeting PAAF activation and ECM dysregulation. These results offer a novel mechanistic foundation for MSC treatment in PAH.

Authors

Institutions

Publication Details

Journal
Stem Cell Research & Therapy
Published
2026-01-05
DOI
https://doi.org/10.1186/s13287-025-04883-5
Primary Topic
Pulmonary Hypertension Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Mesenchymal stromal cells alleviate pulmonary arterial hypertension by suppressing pulmonary arterial adventitial fibroblast activation and extracellular matrix remodeling via the SOCS3/STAT3 pathway

Shiyue Li, Changlei Bao, Jinsheng Zhu, Xiaoxiao Mao et al.
Stem Cell Research & Therapy
Pulmonary Hypertension Research and Treatments
article

Mesenchymal stromal cells alleviate pulmonary arterial hypertension by suppressing pulmonary arterial adventitial fibroblast activation and extracellular matrix remodeling via the SOCS3/STAT3 pathway

Shiyue Li, Changlei Bao, Jinsheng Zhu, Xiaoxiao Mao, Sheng Du, Jing Jin, Jiaojiao Wang, Mengni Zhang, Xinyuan Chen, Xinyu Song
article en

Abstract

Our findings underscore the importance of early intervention in the PAH disease course for MSC-based therapy. MSCs attenuate vascular remodeling and disease progression, possibly through the SOCS3/STAT3 signaling pathway, by targeting PAAF activation and ECM dysregulation. These results offer a novel mechanistic foundation for MSC treatment in PAH.

Stem Cell Research & TherapyVol. 17(1)
Southern University of Science and Technology (CN), First Affiliated Hospital of Guangzhou Medical University (CN), Nanfang Hospital (CN), Shenzhen Third People’s Hospital (CN), Southern Medical University (CN), Guangzhou Medical University (CN)
Good health and well-being
Openalex Percentile: Top 98%
Pulmonary Hypertension Research and Treatments
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Mesenchymal stromal cells alleviate pulmonary arterial hypertension by suppressing pulmonary arterial adventitial fibroblast activation and extracellular matrix remodeling via the SOCS3/STAT3 pathway — Shiyue Li, Changlei Bao, et al. · Stem Cell Research & Therapy (2026) | TGRS Research Map | TGRS