Epigenetic evolution of isocitrate dehydrogenase-wildtype glioblastomas
The methylome of IDHwt glioblastomas is highly stable at tumor progression. In this series, only 7% of tumors showed change in MGMT promoter methylation status at progression.
Authors
- Vincent Bours
- Monique C.J. Hanse
- Kaspar Draaisma (ORCID: https://orcid.org/0000-0002-6003-9607)
- Nicos Angelopoulos (ORCID: https://orcid.org/0000-0002-7507-9177)
- Thierry Gorlia
- Slávka Lukacova (ORCID: https://orcid.org/0000-0002-2875-095X)
- Ann Hoeben (ORCID: https://orcid.org/0000-0003-0155-3005)
- Sieger Leenstra (ORCID: https://orcid.org/0000-0003-3569-2329)
- Youri Hoogstrate (ORCID: https://orcid.org/0000-0003-2166-0676)
- Giuseppe Lombardi
- Pim French
- Colin Watts
- Rania Head
- Ruth E M Fleischeuer
- Pierre A Robe
- Martin J Van Den Bent
- Bo Deng
Institutions
- Radboud University Nijmegen (NL)
- University of Liège (BE)
- Utrecht University (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Erasmus MC (NL)
- Aarhus University Hospital (DK)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Istituto Oncologico Veneto (IT)
- European Organisation for Research and Treatment of Cancer (BE)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Erasmus MC Cancer Institute (NL)
- Imperial College London (GB)
- University of Birmingham (GB)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-12-31
- DOI
- https://doi.org/10.1093/neuonc/noaf298
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00