MCP-1/CCR2 axis regulates M2 macrophage polarization and immunosuppression in mycobacterium tuberculosis
The <i>MCP-1/CCR2</i> axis promotes M2-type macrophage polarization, suppresses apoptosis, and enhances immunosuppressive signaling in the context of H37Ra infection. Targeting <i>CCR2/MCP-1</i> may provide a promising strategy to reverse immune evasion and restore host defense mechanisms during MTB infection.
Authors
- Guizeng Zhao
- Lili Zhang (ORCID: https://orcid.org/0000-0002-3601-0150)
- Xiaoyang Li (ORCID: https://orcid.org/0000-0001-8711-7567)
- Xia Wang (ORCID: https://orcid.org/0009-0008-6521-4938)
- Feng Tian
- Xueyang Chen
- Can Guo
- Junwei Cui
- Lei Tan
Institutions
- Beijing Chest Hospital (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1698369
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00