Synthesis of Cobalt Hydroxychloride and Its Application as a Catalyst in the Condensation of Perimidines
Herein, we report the synthesis, characterization, and catalytic evaluation of cobalt hydroxide chloride [Co<sub>2</sub>(OH)<sub>3</sub>Cl] in the solvent-free synthesis of 2-substituted 2,3-dihydroperimidines. The presented method aligns with several green chemistry principles, offering operational simplicity, purification by recrystallization, no by-product formation, high yields (64-99%), and short reaction times. A total of 16 dihydroperimidines were synthesized to demonstrate substrate scope versatility. Additionally, the catalyst was successfully recycled and reused in multiple cycles without significant loss. Its robustness was further confirmed by gram-scale synthesis, achieving an 89% yield.
Authors
- Gleison Antônio Casagrande (ORCID: https://orcid.org/0000-0002-1667-913X)
- Sumbal Saba (ORCID: https://orcid.org/0000-0002-6134-7249)
- Jamal Rafique (ORCID: https://orcid.org/0000-0002-2336-040X)
- Gabriela Ramos Borges (ORCID: https://orcid.org/0000-0002-9225-2410)
- Giancarlo Viccari Botteselle
- Fernanda Santos Portela (ORCID: https://orcid.org/0000-0001-6517-2995)
- Cássio Siqueira (ORCID: https://orcid.org/0009-0002-8058-9849)
- Maria E. Miks
- Felipe F. Marques
- Rafael Marangoni
Institutions
- Universidade Federal de Mato Grosso do Sul (BR)
- Chemical Synthesis Lab (SG)
- Universidade Federal de Goiás (BR)
Publication Details
- Journal
- Molecules
- Published
- 2026-01-04
- DOI
- https://doi.org/10.3390/molecules31010182
- Primary Topic
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico