Comprehensive Evidence-Based Guidelines for Regenerative Therapies in the Management of Chronic Low Back Pain: 2025 Update from the American Society Of Interventional Pain Physicians (ASIPP).
Based on current evidence, lumbar intradiscal injections of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) are supported by Level III evidence. Lumbar epidural PRP injections are also supported by Level III evidence, while PRP injections for lumbar facet joints and sacroiliac joints are supported by Level IV evidence. Given the emerging status of biologic therapies and the limited quality of existing studies, the panel provides moderate, consensus-based recommendations for the use of all biologics in the lumbar spine.
Authors
- J Hirsch
- Lady Christine Ong Sio (ORCID: https://orcid.org/0000-0002-9157-9016)
- Devi E. Nampiaparampil (ORCID: https://orcid.org/0000-0001-7577-3890)
- Paul J. Christo (ORCID: https://orcid.org/0000-0001-6488-5272)
- Mahendra Sanapati (ORCID: https://orcid.org/0000-0002-1047-0765)
- Sanjay Bakshi
- Nebojša Nick Knežević (ORCID: https://orcid.org/0000-0001-8028-1495)
- Annu Navani (ORCID: https://orcid.org/0009-0002-3873-503X)
- DAJIE WANG
- Sairam Atluri
- Joseph A Cabaret
- Theodore T. Sand (ORCID: https://orcid.org/0000-0002-6197-965X)
- Riya Navani
- Alexander Bautista (ORCID: https://orcid.org/0009-0000-4705-0986)
- Sheri L. Albers
- Vivek Manocha
- Adam M. Kaye (ORCID: https://orcid.org/0000-0002-7224-3322)
- Robert P. Farhat
- Amol Soin
- Aaron K Calodney
- Shounuck Patel
- Saloni Shah (ORCID: https://orcid.org/0000-0002-1483-4562)
- Kenneth D. Candido
- Shivam Shah
- Navneet K. Boddu
- Alaa Abd-Elsayed
- John Santa Ana
- Sheldon Jordan
- Tom Nabity
- Anss Annie Augustine
- Miles R Day
- Vidyasagar Pampati
- Alan D Kaye
- Laxmaiah Manchikanti
- Michael Khadavi
Institutions
- University of the Pacific (US)
- Harvard University (US)
- University of Louisville (US)
- Johns Hopkins University (US)
- Oakland University (US)
- Johns Hopkins Medicine (US)
- University of Illinois Chicago (US)
- Massachusetts General Hospital (US)
- Advocate Illinois Masonic Medical Center (US)
- Pain Management Centers Of America (US)
- Louisiana State University Health Sciences Center Shreveport (US)
- Stanford University (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-12-01
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00