Diclofenac Induced Stevens Johnson Syndrome – Toxic Epidermal Necrolysis Overlap In A HIV-AIDS Patient: A Case Report

Abstract Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. They are associated with significant morbidity and mortality. Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are characterised by serious reaction of the skin and mucous membranes that can be caused by certain medications, infections or autoimmune diseases. Pathophysiology of these conditions has not been fully understood. We report the case of a 45-year-old female who experienced an adverse drug reaction subsequent to the administration of diclofenac 50 mg orally, which had been prescribed for genital pain. Within 24 hours, she developed fever, followed by reddish lesions and painful erosions involving most of her body. Diclofenac was discontinued and systemic steroids were initiated. Close monitoring and management of the symptoms was carried out and the patient recovered completely after an in-patient treatment of 9 days.