Genome-wide DNA methylation patterns for indicators of liver steatosis: a longitudinal multiomic study
Our findings highlight the association between the methylation levels of cg06690548 (SLC7A11) and liver steatosis, describe the dynamic relationship between whole blood DNA methylation and MASLD, and contribute to a deeper understanding of the pathophysiology of liver diseases.
Authors
- Saara Marttila (ORCID: https://orcid.org/0000-0003-3071-3784)
- M. Waldenberger
- M. Kähönen
- Daria Kostiniuk (ORCID: https://orcid.org/0000-0001-7018-6195)
- Emma Raitoharju (ORCID: https://orcid.org/0000-0002-7023-8706)
- Noora Kartiosuo (ORCID: https://orcid.org/0000-0001-7859-0483)
- Sonja Rajić (ORCID: https://orcid.org/0000-0002-0497-3577)
- Marcus E. Kleber (ORCID: https://orcid.org/0000-0003-0663-7275)
- Katja Pahkala (ORCID: https://orcid.org/0000-0001-9338-4397)
- J Mykkänen
- Liye Lai
- Suvi P. Rovio
- Ella Raulamo
- Terho Lehtimäki
- Leo-Pekka Lyytikäinen
- Olli Raitakari
- Jo Ciantar
- Annette Peters
- Juliane Winkelmann
- Pashupati P. Mishra
- Winfried März
Institutions
- Tampere University of Applied Sciences (FI)
- University of Turku (FI)
- Tampere University (FI)
- Zimmer Biomet (Netherlands) (NL)
- Heidelberg University (DE)
- Turku University Hospital (FI)
- University Hospital Heidelberg (DE)
- Helmholtz Zentrum München (DE)
- Paavo Nurmen Säätiö (FI)
- Pirkanmaa Hospital District (FI)
- Tampere University Hospital (FI)
- Synlab (Germany) (DE)
- German Centre for Cardiovascular Research (DE)
- Tampere University (FI)
- Fimlab (Finland) (FI)
- Deutsches Diabetes-Zentrum e.V. (DE)
- University Medical Centre Mannheim (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1186/s13148-025-02037-1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00