Fuzheng Jiedu formula attenuates acute pneumonia by coordinated regulation of macrophage NLRP3 inflammasome and neutrophil NETs
FZJD mitigates acute pneumonia by dampening macrophage NLRP3 inflammasome activation while restraining neutrophil NETosis. The mechanistic study provides evidence supporting the traditional use of FZJD in the treatment of respiratory infections and underscores its potential as a host-directed therapy.
Authors
- WenShuang Wang
- Jin Yan (ORCID: https://orcid.org/0000-0003-2384-1171)
- Man Zhang (ORCID: https://orcid.org/0000-0003-2834-0173)
- Fuyun Chi
- Kaixin Liu (ORCID: https://orcid.org/0000-0001-6778-1591)
- Gang Bai
- Yuanyuan Hou
Institutions
- Nankai University (CN)
- State Key Laboratory of Medicinal Chemical Biology
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-04
- DOI
- https://doi.org/10.1186/s13020-025-01281-0
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00