miR-376c-3p mediates icariin’s anti-osteoclastogenic effect by targeting Mmp3

Our findings demonstrate that ICA exerts its anti-osteoporotic effect by downregulating the miR-376c-3p-mediated Mmp3 expression. This study provides insights that potentially facilitate ICA's clinical application.

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Publication Details

Journal
Journal of Orthopaedic Surgery and Research
Published
2026-01-04
DOI
https://doi.org/10.1186/s13018-025-06589-z
Primary Topic
Medicinal Plant Pharmacodynamics Research
Type
article
Field-Weighted Citation Impact
0.00
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article

miR-376c-3p mediates icariin’s anti-osteoclastogenic effect by targeting Mmp3

Yunteng Xu, Jiapo Zuo, Jingdi Li, Hui Yan et al.
Journal of Orthopaedic Surgery and Research
Medicinal Plant Pharmacodynamics Research
article

miR-376c-3p mediates icariin’s anti-osteoclastogenic effect by targeting Mmp3

Yunteng Xu, Jiapo Zuo, Jingdi Li, Hui Yan, Yaoting Zou, Dezun Ma, Dingbang Xie
article en

Abstract

Our findings demonstrate that ICA exerts its anti-osteoporotic effect by downregulating the miR-376c-3p-mediated Mmp3 expression. This study provides insights that potentially facilitate ICA's clinical application.

Journal of Orthopaedic Surgery and ResearchVol. 21(1)
Fujian University of Traditional Chinese Medicine (CN), Ministry of Education (TH)
Openalex Percentile: Top 97%
Medicinal Plant Pharmacodynamics Research
DOIOpen Access PDFOpenAlex
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