High-CD14-expressing urothelial cancer cells foster a neutrophil-rich tumor microenvironment that increases the risk of radiation-promoted distant metastasis
CD14 expression in tumor cells plays a pivotal role in shaping a neutrophil-enriched TME, which increases the susceptibility to RT-promoted DM. CD14 represents a potential predictive biomarker and therapeutic target for mitigating this adverse outcome.
Authors
- Shih-Chieh Jeff Chueh
- Yun Chiang (ORCID: https://orcid.org/0000-0002-2336-4603)
- Cheng Jason Chia-Hsien
- Fu-Jen Hsueh (ORCID: https://orcid.org/0009-0000-6484-0090)
- Chen-Chung Hsin
- Chaoyuan Huang (ORCID: https://orcid.org/0000-0002-2227-7276)
- Yeong-Shiau Pu
- Xavier Cheng-Hong Tsai (ORCID: https://orcid.org/0000-0002-4174-8766)
- Chung-Chieh Wang
- Yu-Chieh Tsai
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-01-04
- DOI
- https://doi.org/10.1186/s12929-025-01201-2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council