Sex-dependent effects of ultra-low-dose-THC preventive treatment on neuroinflammation and cognitive decline in 5xFAD mice
These findings highlight ULD-THC's potential as a preventive strategy for AD, emphasizing the importance of sex-dependent therapeutic approaches. By attenuating neuroinflammatory processes before cognitive deficits fully manifest, ULD-THC offers a novel, biologically targeted approach to AD prevention. Future research should explore its long-term efficacy and translational potential in clinical settings.
Authors
- Ravid Doron (ORCID: https://orcid.org/0000-0002-6523-9886)
- Emanuela P. Break
- Dekel David (ORCID: https://orcid.org/0000-0002-5136-9145)
- Ziv Bentulila (ORCID: https://orcid.org/0000-0001-6751-6800)
- Keren Nitzan (ORCID: https://orcid.org/0000-0001-6193-9431)
- Noa Bregman-Yemini
- Yossi Sarne
- Niv Ayalon
Institutions
- Tel Aviv University (IL)
- Open University of Israel (IL)
- Hebrew University of Jerusalem (IL)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1186/s13293-025-00815-3
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00