Clinical spectrum, immune status, and prognostic factors of cryptococcosis: insights from a large, multi-center, ambispective cohort study in southeastern China
Host immune status, CNS involvement, and systemic inflammation are key predictors of outcome in cryptococcosis. Quantitative and qualitative CrAg assays demonstrate high diagnostic performance and azole monotherapy remained effective for pulmonary disease. These findings support risk-stratified diagnostic and therapeutic strategies in routine clinical practice, particularly in resource-limited settings.
Authors
- X H Chen
- Z. Liu
- W. Liu
- Lei Gu (ORCID: https://orcid.org/0000-0003-4035-3583)
- Jun Huang (ORCID: https://orcid.org/0000-0002-7837-653X)
- Jian Yue (ORCID: https://orcid.org/0009-0009-9868-0959)
- Guoxiang Lai
- Jing Lin (ORCID: https://orcid.org/0000-0001-9085-8307)
- Jun Wu (ORCID: https://orcid.org/0000-0003-3227-4818)
- Xiangqi Chen (ORCID: https://orcid.org/0000-0003-1189-5789)
- Qunying Lin
- Baosong Xie
- Wen Wen
- Anmao Li
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- Zunyi Medical University (CN)
- Soochow University (CN)
- Second Hospital of Nanchang (CN)
- Fuzhou Pulmonary Hospital of Fujian (CN)
- First Affiliated Hospital of Soochow University (CN)
- Union Hospital (CN)
- Gaozhou People's Hospital (CN)
- Putian University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Infectious Diseases of Poverty
- Published
- 2026-01-04
- DOI
- https://doi.org/10.1186/s40249-025-01408-3
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Soochow University