Ceftazidime/avibactam and ceftolozane/tazobactam for severe paediatric infections: A systematic review, meta-analysis, and evidence map
CZA and C/T appear promising for paediatric cUTI and complicated intra-abdominal infections, but the evidence base remains narrow and largely dependent on small, industry-funded trials. Independent RCTs including critically ill children and resistant infections are urgently needed.
Authors
- Valcieny Souza Sandes (ORCID: https://orcid.org/0000-0003-0006-9350)
- Fernando Fernández-Llimós (ORCID: https://orcid.org/0000-0002-8529-9595)
- Thaís Gouvêa
- Paula Pimenta-de-Souza (ORCID: https://orcid.org/0009-0008-8231-5706)
- Elisangela Costa LIMA
- Alice Ramos-Silva
- Patrícia Portella
Institutions
- Universidade do Porto (PT)
- Czech Academy of Sciences, Institute of Biophysics (CZ)
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107710
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 21.79