Plasma supplemented with glycine is superior to standard plasma in reducing vascular permeability and organ injury via reduction of inflammation in an experimental traumatic shock model

Glycine-supplemented plasma is superior to standard plasma in preventing endothelial permeability, glycocalyx shedding, and lung injury, which may be mediated via inhibition of IL-6 or improvement of acid-base balance. The use of solvent detergent plasma for trauma resuscitation may be more beneficial than standard plasma, partly due to glycine content.