TNA in Fertility and Reproductive Systems: Throughput, Incoherence, and Reproductive Stability

Aging is traditionally modeled through telomere shortening, mitochondrial decline, and cumulative molecular damage. This paper applies the Theorem of Axiomatic Necessity (TNA) to aging, framing the organism as an open non-equilibrium system where longevity and functional stability require continuous throughput (Ψ) to discharge incoming incoherence (G). When G exceeds Ψ, incoherence (ℵ) accumulates as cellular damage, senescence, and organ dysfunction. Phenomena such as frailty, sarcopenia, cognitive decline, and chronic disease are reframed as throughput saturation rather than inevitable failure. The model is falsifiable, predictive, and integrates metabolic, neurological, cardiovascular, endocrine, and immune axes under a single mechanical principle.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-03
DOI
https://doi.org/10.5281/zenodo.18141126
Primary Topic
Genetics, Aging, and Longevity in Model Organisms
Type
article
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article

TNA in Fertility and Reproductive Systems: Throughput, Incoherence, and Reproductive Stability

Claudio Bresciano
Zenodo (CERN European Organization for Nuclear Research)
Genetics, Aging, and Longevity in Model Organisms
article

TNA in Fertility and Reproductive Systems: Throughput, Incoherence, and Reproductive Stability

Claudio Bresciano
article en

Abstract

Aging is traditionally modeled through telomere shortening, mitochondrial decline, and cumulative molecular damage. This paper applies the Theorem of Axiomatic Necessity (TNA) to aging, framing the organism as an open non-equilibrium system where longevity and functional stability require continuous throughput (Ψ) to discharge incoming incoherence (G). When G exceeds Ψ, incoherence (ℵ) accumulates as cellular damage, senescence, and organ dysfunction. Phenomena such as frailty, sarcopenia, cognitive decline, and chronic disease are reframed as throughput saturation rather than inevitable failure. The model is falsifiable, predictive, and integrates metabolic, neurological, cardiovascular, endocrine, and immune axes under a single mechanical principle.

Zenodo (CERN European Organization for Nuclear Research)
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Genetics, Aging, and Longevity in Model Organisms
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