A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells
Our study uncovers the previously underappreciated heterogeneity and functional diversity of DNT cells in the TME and demonstrates their profound impact on tumor progression and immunotherapy outcomes.
Authors
- C. X. Huang
- Qing Hao
- Xuyang Xia (ORCID: https://orcid.org/0000-0003-4230-7265)
- Huayun Yan
- Huina Xu
- Tao Zhou (ORCID: https://orcid.org/0000-0002-9265-4946)
- Yitao Wang (ORCID: https://orcid.org/0000-0002-1041-1917)
- Yifan He (ORCID: https://orcid.org/0009-0001-8664-037X)
- Minqin Xiao
- Libing Huang (ORCID: https://orcid.org/0000-0002-3413-3499)
- Huiyuan Zhang (ORCID: https://orcid.org/0000-0002-5557-3645)
- Zhixiang Ren
- Wei-Han Zhang (ORCID: https://orcid.org/0000-0002-4899-9285)
- Wei Mao
- Yu Xu
- Yang Luo
- Yang Shu
- Yong Peng
- Maoxiang Qian
- Hai-Ning Chen
- Feng Zhang
- Lunzhi Dai (ORCID: https://orcid.org/0000-0002-3003-8910)
- Li Yang
- Yue-yun Chen
- Jing Wu
Institutions
- Sun Yat-sen University (CN)
- Sichuan University (CN)
- Fudan University (CN)
- Quzhou City People's Hospital (CN)
- West China Hospital of Sichuan University (CN)
- Quzhou University (CN)
- Chongqing Emergency Medical Center (CN)
- Sun Yat-sen University Cancer Center (CN)
- Children's Hospital of Fudan University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1186/s12943-025-02548-8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00