Type I interferon drives dysfunction of a distinct CD8+ HLA-DRB1+ T cell subset in systemic lupus erythematosus
CD8+ HLA-DRB1+ T cells represent a cytotoxic yet dysfunctional effector memory population expanded in SLE. Type I IFN drives this paradoxical state by promoting exhaustion and impaired degranulation, highlighting a potential therapeutic axis in SLE.
Authors
- Amr H. Sawalha (ORCID: https://orcid.org/0000-0002-3884-962X)
- H. Long
- Elio G. Carmona (ORCID: https://orcid.org/0000-0003-1315-5469)
- Mikhail Dozmorov
Institutions
- Central South University (CN)
- University of Pittsburgh (US)
- Virginia Commonwealth University (US)
- Children's Hospital of Pittsburgh (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-03
- DOI
- https://doi.org/10.64898/2026.01.02.26343348
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00