Daphnetin Ameliorates the Amyloid β-Induced Alzheimer Disease via Restoring Potassium-Chloride Co-Transporter 2 (KCC2) Ion Channel Functions in Mice

Daphnetin attenuates Aβ-associated AD progression via inhibition of AChE activity, scavenging of free radicals, reduction of inflammation, and restoration of neuronal KCC2 channels. Hence, it may be a potential therapeutic agent for the treatment of AD. However, more extensive studies are required to confirm this therapeutic potency in different AD conditions and various animal species.