Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach
This study elucidates the mechanisms of TXA-induced EP through network toxicology and molecular docking, confirming its interference with GABA-related targets and neural suppression functions. The study overcomes the limitations of traditional toxicology, providing a scientific basis for the safe use of TXA and prevention of neurotoxicity.
Authors
- Xiangyang Leng (ORCID: https://orcid.org/0000-0001-6385-5370)
- D. Liu
- Tianqi Gao (ORCID: https://orcid.org/0000-0002-0577-1352)
- Yan Ting Gu
- Tao Chen (ORCID: https://orcid.org/0000-0002-0853-8716)
- Xiaojiang Li
Institutions
- Changchun University of Chinese Medicine (CN)
- Changchun University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1186/s12916-025-04605-x
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00