Analysis of Health System Preparedness for Monkeypox Response in Benin

Introduction: Benin, as a West African country sharing borders with high-risk areas, is on the front lines of the threat of Monkeypox (Mpox) epidemics. This study aimed to assess the preparedness of the Beninese health system for this emerging zoonotic risk. Method: A cross-sectional, descriptive, and qualitative approach was conducted from April to September 2025, structured into three phases: documentary analysis of national regulatory documents, interviews with strategic managers (central and departmental directorates), and direct observation of Epidemic Treatment Centers (ETCs). Results: The analysis revealed a robust regulatory framework (National Preparedness and Response Plan for Monkeypox, updated Standard Operating Procedures (SOPs)) aligned with the International Health Regulations (IHR 2005). Interviews confirmed strong inter-institutional coordination, led by the Public Health Emergency Operations Center (PHEOC). Observation of the ETCs revealed high operational capacity, with trained human resources, Personal Protective Equipment (PPE), and medical supplies satisfactorily prepositioned. Conclusion: These results demonstrate good overall preparedness of the Beninese health system, transforming lessons learned from previous crises into a proactive and organized response strategy, although the sustainability of logistical supplies and regular simulation exercises must remain a priority.