Time-dependent effects in consecutive cycles of prone positioning for acute respiratory failure: insights from the PROVENT-C19 Registry

ICU survivors consistently demonstrated better oxygenation and more stable ventilatory ratio across studied prone positioning cycles, whereas non-survivors showed worsening oxygenation when returning supine and increased ventilatory ratio. Additionally, extending the duration of prone position beyond the second cycle may not significantly impact mortality.

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Publication Details

Journal
Journal of Anesthesia Analgesia and Critical Care
Published
2026-01-03
DOI
https://doi.org/10.1186/s44158-025-00318-y
Primary Topic
Respiratory Support and Mechanisms
Type
article
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article

Time-dependent effects in consecutive cycles of prone positioning for acute respiratory failure: insights from the PROVENT-C19 Registry

Vincenzo Bosco, Jacopo Lion, Rosa Fracchia, Moataz Maher Emara et al.
Journal of Anesthesia Analgesia and Critical Care
Respiratory Support and Mechanisms
article

Time-dependent effects in consecutive cycles of prone positioning for acute respiratory failure: insights from the PROVENT-C19 Registry

Vincenzo Bosco, Jacopo Lion, Rosa Fracchia, Moataz Maher Emara, Elena Munari, F. Terranova, Elisa Gamberini, Alessandra Soragni, MASSIMO GIRARDIS, Mercedes Gori, Emanuele Rezoagli, Federico Geraldini, Luigi Vetrugno, Francesco Marrazzo, Eugenio Biamonte, Francesco Saglietti, Chiara Schiavolin, Debora Saggioro, Beatrice Milan, Alfonso Carrara, Michele Salvagno, Nicoletta Boffa, Daniela Alampi, Ivo Tiberio, Regina Frontera, Annalisa Benini, Sara Frisella, E Othman, Aurora Magliocca, Leonardo Gandolfi, T. Tenaglia, Elisa Furlani, Salvatore Maurizio Maggiore, Caterina Simoni, Amedeo Guzzardella, Federico Linassi, Rita Vaia Liouras, Silvia Corrado, Giacomo Paluzzano, Maria Cristina Bisi, Enrico Polati, Hashim Talib Hashim, Monica Geremia, Emiliano Gamberini, G. Panciera, Erika Roat, Michela Bombino, Giulia Torsello, Alvise Martini, Elisabetta Saraceni, V Cricca, Francesco Salvo, Irene Coloretti, Marta Talamonti, Maria Maddalena Bitondo, Elisa Bonetta, Haitam Shames, A. Corea, Amer Aldhalia, Martina Cedrone, Gloria Boscolo, Giovanni Carmine, Maytham Al-Juaifari, Edoardo Forin, Sabrina Congedi, Lorenzo Dall’Ara, Marco Berti, Salvatore Simari, Mohamed Abdel-Maboud, Romina Aceto, Alice Nova, Guido Bussone, Andrea Rodi, Ilaria Godi, Salvatore Di Blasi, Riccardo La Rosa, Enrico Andriolo, Monica Rocco, Benvenuto Antonini, Maiseloon Mostafa Mogahed, Nicola Franchetti, Mohammed Al‐Sadawi, Letizia Troisi, Sara Vergine, Francesco Zarantonello, Leonardo Gottin, Marta Lubian, Fabio TOFFOLETTO, Ilenia Gatto, Fabrizio Turvani, Stefano Addesa, Chiara Crivellari, Anita Orlando, Riccardo Carlon, Andrea Bianchin, Marco Anderloni, Chiara Bruscagnin, Silvia De Rosa, Katia Donadello, Abdurraouf Abusalama, Veronica Bozzon, A Kredan, Luca Serano, Nicolò Martinetti, Jonathan Montomoli, Anna Marinello, Matteo Perona, Alberto Grassetto, Simone Antonio Smiraglia, L Giuntoli, Lorenza Moretto, Annalisa Boscolo, Nicola Cilloni, Lorenzo Gamberini, Busani Stefano, Muhannud Binnawara, Pierluigi Di Giannatale, Massimo Ferluga, Francesco Papaccio, Lucia Cattin, Giorgio Fullin, Matteo Cesana, Vanessa Zambelli, Jacopo Rama, Vittorio Schweiger, Francesca Ceccaroni, E Finotto, Luigi Tritapepe, Chiara Natalia Tartivita, Maurizio Cecconi, Luca Di Tizio, Daniele Poole, G. Luccarelli, Alessandra Gioia Francesconi, Denise Testini, Massimiliano Greco, Vinicio Danzi, Gian Marco Anzellotti, Lucía Alessandra, Antonella Lombardo, Andrea Zanoletti, Jessica Giuseppina Maugeri, Flavio Badii, Carola Santi, Giulia Catalisano, Emanuela Biagioni, Marina Martin, Ilaria Mariani, Mirca Fabbris, Mattia Bellandi, Giorgio MAIORELLI, Nicoletta Nuzzo, Annalisa Pitino, Francesco Berruto, Elena Momesso, Annalisa Lerose, Davide Raimondi Cominesi, Fabrizio Tritapepe, Luca Davicco, Alessandro Bristot, Mara Ricci, Hibah Bileid Bakeer, Mattia Barotti, Riccardo Colombo, Andrea Restivo, Angelo Pezzi, Andrea Bruni, Enrico Colombo, Elena Serafini, Daniela Guerra, Pietro Caironi, Antonino Di Fede, Eugenio Garofalo, Marco Nardelli, S. Spadaro, Raja Ahmed Alqandouz, Haneen Esaadi, Federica Mazzanti, Aliae AR Mohamed Hussein, Antonio Castelli, Luigi Ferrante, Marzia Bellin, Andrea Ballin, Marilena Matteo, Giacomo Berta, Ginevra Randon, A. Cortegiani, Alberto Lucchini, Marcella Parente, Marcello Ceola Graziadei, Andrea Maria Olivieri, Mara Bassi, Mariachiara Ippolito, Veronica Rizzello, Michela Zardin, Eissa Abdullah Mohammed Farea Abdullah, Tommaso Travaglini, Tommaso Pettenuzzo, S. Ongaro, Federico Longhini, Dario Gregori, Agrippino Bellissima, Fabio Soccorsi, Elisa Boni, Aziza Bakri, Matteo Aritzu, Federica Pavan, Ahmed K. Awad, Reem Salih, Paola Vergano, Abdelfatah Abdellateef Abdelmageed, Silvana Sorrentino, Anna Toniolo, Michele Pagani, Abdurraouf Said, Silvia Gasperi, Teresa Iob, Marta Repishti, Morena Tonzar, Francesco Talarico, Paolo Valente, Matteo Pozzi, Stefano Isgrò, Francesca Zini, Tiffany Calocero, Massimo Barattini, Manuela Biasetto, Roberto Fumagalli, Gaetano Scaramuzzo, Lorenza Menato, Nicola Cornacchia, Marco Abastanotti, for the SIAARTI Study Group, Silvia Mongodi, Luca Melchior, Antonella Prandini, Giuseppe Foti, Melissa Polo Fritz, Giacomo Bianchetti, Sara Borga, Ettore Martinez, Luna Di Matteo, Claudine Canepa, Luca Brazzi, Alessandro De Cassai, Valerio Schinetti, Zoe Parimisi, Benedetta Bonazzi, Botto Anna, Linda Ramahi, Laila Esnoussi, Maria Sole, Nicolò Sella, Giacomo Bellani, Luca Landolfi, Muhammed Elhadi, James Mattson, Francesco Filippone, Francesca Medici, Giorgia Montrucchio, Teodora Serana, Gallo Elisa, Vincenzo Russotto, Tareg Abdalla Abuzaid, Nicoletta Predonzani, Aymen Abuelyamen, Stefano Spina, Paolo Navalesi, Paolo Persona, Wanda Cursio, Ernesto Dalla Mora, Giuseppe Neri, Abdulmuhaymin Khalleefah, Matteo Campagnolo, Laura Pasin, Mario Peta, Antonio Grande, Abdurrahman Haddud, Beatrice Gottardi, Giovanni Luigi Tripepi, Giuseppe Moschini, Chiara Donatelli, Valesano Paolo, Risoli Alessio, Marco Giani, Thomas Langer, Blangetti Ilaria, Mostafa Zanaty, Bernardetta Ganzerla, Ilaria Fior, Graziella D’Arrigo, Martina Cavinato, Giulia Lorenzoni, Elisa Pistollato, Chiara Premoli, Davide Ottolina, Tommaso Fossali, Gabriele Sales, Cristina Jovinelli, Egle Rondelli, Gianlorenzo Golino, Antonia Di Giannantonio, Abdulhamid Ahmed Saliga, Deyaa Elden Elbakheet, Niccolò Brumana, Roberto Rona, Sara Olivieri, Claudio La Spisa, Eugenia Zoppellaro, Cannone Andrea, Francesco Mojoli, Alessandro Devigili, Giulia Lo Scrudato, Ahmed Mohammed Abodina, Giovanni Di Noto, Jacopo Santi, Rosella Nicoletti, Antonio Massimo Sammarco
article en

Abstract

ICU survivors consistently demonstrated better oxygenation and more stable ventilatory ratio across studied prone positioning cycles, whereas non-survivors showed worsening oxygenation when returning supine and increased ventilatory ratio. Additionally, extending the duration of prone position beyond the second cycle may not significantly impact mortality.

Journal of Anesthesia Analgesia and Critical CareVol. 6(1)
University of Padua (IT), University of Trento (IT), University of Tripoli (LY), Magna Graecia University (IT), University of Chieti-Pescara (IT), Azienda Ospedaliera Universitaria Integrata Verona (IT), Ospedale di San Donà di Piave (IT), Istituto di Fisiologia Clinica (IT), Ospedale dell' Angelo (IT), Ca' Foncello Hospital (IT), Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT), Ospedale SS. Annunziata (IT), Ospedale San Bortolo (IT), Ospedale Civile di Vittorio Veneto (IT), Ospedale di Santa Maria dei Battuti (IT), University of Milano-Bicocca (IT), University of Palermo (IT)
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