Real-world safety data of first-line drugs for rheumatoid arthritis: insights from the Portuguese Reuma.pt database.
AE related to first-line RA therapies can lead to significant clinical consequences, including treatment discontinuation. Male sex and advanced age were associated with increased AE severity. The most affected systems appear consistent with known drug safety profiles, particularly that of methotrexate; however, the absence of information regarding drug dosage precludes more detailed conclusions. These findings emphasize the need for individualized monitoring strategies and improved pharmacovigilance to optimize long-term treatment safety and adherence in RA management.
Authors
- Ana Cláudia Raposo (ORCID: https://orcid.org/0000-0002-3574-3723)
- Luís Inês (ORCID: https://orcid.org/0000-0003-3172-3570)
- Ana Águeda (ORCID: https://orcid.org/0000-0001-9984-8084)
- Ana Catarina Moniz (ORCID: https://orcid.org/0000-0002-7343-1181)
- Patrícia Nero
- Maria Francisca Magalhães
- Ana Valido (ORCID: https://orcid.org/0000-0001-5412-2642)
- Helena Assunção (ORCID: https://orcid.org/0000-0002-8849-3828)
- Catarina S. Silva (ORCID: https://orcid.org/0000-0002-7392-7670)
- Filipa Farinha (ORCID: https://orcid.org/0000-0002-1517-4383)
- Carla Campinho Ferreia
- Cátia C. M. Duarte (ORCID: https://orcid.org/0000-0001-9327-6935)
- Helena Lourenço (ORCID: https://orcid.org/0000-0002-3495-238X)
- Cláudia Miguel
- Manuel Morgado (ORCID: https://orcid.org/0000-0003-2112-2835)
- Inês Sopa (ORCID: https://orcid.org/0009-0003-8072-3451)
- Mariana Emília Santos (ORCID: https://orcid.org/0009-0000-4087-4202)
- Helena Santos (ORCID: https://orcid.org/0000-0003-3682-5840)
- Mariana Diz Lopes
- Susana Almeida
- Ana Catarina Duarte (ORCID: https://orcid.org/0000-0001-6128-2425)
- Pedro Pereira (ORCID: https://orcid.org/0000-0001-7835-4755)
- Ana Cristina Cordeiro
- Marina Oliveira
- Susana Emídio Matias
- Maria Pontes Ferreira (ORCID: https://orcid.org/0009-0008-3831-3527)
- Catarina R Rua
- Duarte Augusto (ORCID: https://orcid.org/0009-0004-9311-8493)
- Miguel Bernardes (ORCID: https://orcid.org/0000-0002-1849-5465)
- A. Vilar (ORCID: https://orcid.org/0009-0003-6465-1507)
- Carlos Marques Gomes
- Daniel Melim
- Catarina Abreu
- Filipe Pinheiro
- Anita Cunha
- João Lagoas Gomes
- Ana Teodósio Chícharo
- Joana Ramos Rodrigues
- Rita Fonseca
- José Tavares-Costa
- Margarida Oliveira
- Leonor Reynolds
- Filipa Canhão André
- Daniel Carvalho
- Joaquim Polido Pereira
- Marília Rodrigues
- João Dias
- Filipe Araújo
- José António Pereira Silva
- Maura Couto
- Ana Filipa Mourao
- Luís Silva Pires
- Teresa Melo
- Ana Rita Vieira
- Vítor Silvestre Teixeira
- Pedro Miguel Teixeira
- Sara Alves Costa
- Graça Sequeira
- Jorge Garcia
- João Aguiar
Institutions
- Hospitais da Universidade de Coimbra (PT)
- Hospital de São João (PT)
- Instituto Superior de Espinho (PT)
- Universidade Politécnica da Guarda (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Instituto Português de Malacologia (PT)
- Centro Hospitalar de Lisboa Ocidental (PT)
- Hospital Braga (PT)
- Hospital Garcia de Orta (PT)
- Hospital do Desterro (PT)
- Hospital CUF Descobertas
- Instituto Português de Reumatologia
Publication Details
- Journal
- PubMed
- Published
- 2026-01-02
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00