Spray Gel Extract of Karsen Leaves <i>(Muntingia Calabura L.)</i> can Control Inflammation and Enhance Proliferation in Second-Degree Burns.

The study investigates the potential of Karsen leaves <i>(Muntingia calabura L.)</i> extract in spray gel form to aid the healing of second-degree burns. This experimental research assesses the effects of the extract on key inflammatory and proliferative indicators: wound temperature, erythema, skin moisture and wound contraction. Rats with induced burns were treated with varying concentrations (12.5%, 15% and 17.5%) of the extract over 14 days. Results demonstrated that the 15% concentration effectively managed wound base temperature and enhanced wound contraction, while the 17.5% concentration significantly reduced erythema and retained skin moisture in the proliferative phase. These findings suggest that Karsen leaves extract in spray gel form has promising therapeutic benefits for burn wound healing. Further research could enhance formulation efficacy and expand its clinical applications.