Hsa_circ_PCNT sponges hsa-miR-133b to promote SHH medulloblastoma via TAGLN2
The results show that hsa_circ_PCNT promotes SHH-MB aggression through the hsa-miR-133b /TAGLN2 pathway. In summary, our research demonstrates that hsa_circ_PCNT occupies a crucial position in SHH-MB and emerges as a potential therapeutic target.
Authors
- Chenran Zhang (ORCID: https://orcid.org/0000-0002-4595-6941)
- Runxi Fu (ORCID: https://orcid.org/0000-0001-6513-3152)
- Jinlong Yu (ORCID: https://orcid.org/0000-0002-4581-1726)
- Y. Wang
- Hu Li (ORCID: https://orcid.org/0000-0002-7917-7807)
- Yufan Chen (ORCID: https://orcid.org/0000-0001-7989-3283)
- Yunkun Wang
- Ying Yu
- Tianlang Hu
- Cheng Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- XinHua Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1007/s00018-025-06048-2
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00