Cognitive dysfunction in type 1 diabetes: role of TREM2 in microglial activation and Aβ pathology
These findings establish TREM2 as a critical regulator of microglial Aβ clearance in T1D, operating mitochondrial and phagocytic programs via mTOR and highlighting its therapeutic potential for diabetic neurodegeneration.
Authors
- M. Sun
- Yimeng Liu (ORCID: https://orcid.org/0000-0002-9433-5092)
- Ziwei Wang (ORCID: https://orcid.org/0000-0003-1324-2298)
- Yue Wang
- Li Zhao
- Hongyan Ding
- Ruyue Wang
- Xinyi Wei
- Aikeda Aihemaitijiang
Institutions
- Capital Medical University (CN)
- Cangzhou Central Hospital (CN)
- Beijing Anding Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1186/s12974-025-03611-3
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 30.63