HBV RNA at 6 months after nucleos(t)ide analogues treatment can predict antiviral efficacy in chronic hepatitis B patients
HBV RNA dynamics transition from DNA- to HBsAg-associated correlations during NA therapy. Early declines in HBV DNA/RNA at 6 months predict VR and HBeAg seroconversion, establishing this time as a a robust and clinically practical early prediction point. HBV RNA complements existing biomarkers for optimizing CHB management.
Authors
- X. X. Zhang (ORCID: https://orcid.org/0009-0007-2242-6503)
- Sujun Zheng
- Xiaozhou Yang (ORCID: https://orcid.org/0000-0003-3586-4645)
- Peng Yin (ORCID: https://orcid.org/0000-0002-8289-361X)
- Lizhong Dai (ORCID: https://orcid.org/0009-0006-6448-5846)
- Xuefei Duan
- S. Y. Zhang
- Juan Liu (ORCID: https://orcid.org/0000-0002-3080-0098)
- Haiyan Kang (ORCID: https://orcid.org/0000-0002-4348-3810)
- Bo Feng (ORCID: https://orcid.org/0000-0002-9735-845X)
- F. Lu
- Wenpin Cai (ORCID: https://orcid.org/0000-0002-2819-6389)
- Yandi Xie
- Xinghuan Ma
- Xiaoying Zhang
Institutions
- Zhejiang Chinese Medical University (CN)
- Harbin Medical University (CN)
- Capital Medical University (CN)
- Dalian Medical University (CN)
- Peking University (CN)
- Wenzhou Medical University (CN)
- Wenzhou Hospital of Traditional Chinese Medicine (CN)
- Fifth Hospital of Shijiazhuang (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Tianjin People's Hospital (CN)
- Peking University People's Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Hangzhou Xixi hospital (CN)
- Beijing YouAn Hospital (CN)
- Beijing Ditan Hospital (CN)
- Sansure Biotech (China) (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1186/s12876-025-04579-3
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00