Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1

This study provides evidence that hypoxia mediates TMZ resistance in GBM through the HIF-1α/PRMT6/G3BP1 axis, identifying PRMT6 and G3BP1 as promising therapeutic targets to overcome chemoresistance.

Authors

S S Chen
Guangyu Li (ORCID: https://orcid.org/0000-0002-6338-2507)
Peng Yu
Boxiang Zhang
Yuting Yan
Yongqing Sun

Institutions

First Hospital of China Medical University (CN)
China Medical University (CN)

Publication Details

Journal: Journal of Translational Medicine
Published: 2026-01-02
DOI: https://doi.org/10.1186/s12967-025-07618-5
Primary Topic: Cancer-related gene regulation
Type: article
Field-Weighted Citation Impact: 0.00

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article

Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1

S S Chen, Guangyu Li, Peng Yu, Boxiang Zhang et al.

Jan 2, 2026

Journal of Translational Medicine

Cancer-related gene regulation

article

Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1

S S Chen, Guangyu Li, Peng Yu, Boxiang Zhang, Yuting Yan, Yongqing Sun

January 2, 2026article en

Abstract

Journal of Translational MedicineVol. 24(1)

First Hospital of China Medical University (CN), China Medical University (CN)

Openalex Percentile: Top 98%

Cancer-related gene regulation

DOI Open Access PDF OpenAlex

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