Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics
This study presents Palette, a pipeline for integrating bulk RNA-seq data and spatial transcriptomics data, and zSTEP, a comprehensive cartographic resource for investigating zebrafish early embryonic development. In addition, key morphogens and transcriptional factors essential for anteroposterior axis establishment and refinement are identified.
Authors
- Yang Dong (ORCID: https://orcid.org/0000-0002-4810-2730)
- Xinxin Fu (ORCID: https://orcid.org/0000-0001-9206-2265)
- Xianfa Yang (ORCID: https://orcid.org/0000-0002-6843-8055)
- Haoran Li (ORCID: https://orcid.org/0009-0005-2375-9188)
- Zhi-Wen Bian
- Ling-En Yang
- Yuxiang Hu (ORCID: https://orcid.org/0009-0005-8536-3840)
- Tao Cheng (ORCID: https://orcid.org/0000-0002-3056-8137)
- Naihe Jing (ORCID: https://orcid.org/0000-0003-3821-6248)
- Peng-Fei Xu
- Xiang Liu
- Jie Liao
- Xiaohui Fan
Institutions
- National University of Singapore (SG)
- Huazhong Agricultural University (CN)
- Ministry of Education (KR)
- Institute of Human Genetics (PL)
- Zhejiang Modern Chinese Medicine and Natural Medicine Research Institute (China) (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1186/s13059-025-03917-8
- Citations
- 1
- Primary Topic
- Developmental Biology and Gene Regulation
- Type
- article
- Field-Weighted Citation Impact
- 22.24