Aging, matrix metalloproteinase imaging, and survival prospects in aortic aneurysm
Aging is associated with increased MMP activity along the aorta and worse AA survival. MMP-targeted molecular imaging can inform the aneurysm survival prospects. Selective MMP inhibitors and tracers may help prevent and track aneurysm growth, dissection, and rupture.
Authors
- Robert J. Gropler (ORCID: https://orcid.org/0000-0002-6550-0570)
- Onur Varli
- Afarin Neishabouri
- Mean Ghim (ORCID: https://orcid.org/0000-0002-0723-3662)
- Azmi A. Ahmad (ORCID: https://orcid.org/0000-0003-0326-440X)
- Jakub Toczek (ORCID: https://orcid.org/0000-0003-0639-8075)
- Nicholas T. Gangemi (ORCID: https://orcid.org/0000-0002-2899-1438)
- ZhengXing Zhang (ORCID: https://orcid.org/0009-0003-6448-338X)
- Mehran M. Sadeghi (ORCID: https://orcid.org/0000-0002-5074-3510)
- Gunjan Kukreja (ORCID: https://orcid.org/0000-0002-1913-7387)
- Jiasheng Zhang (ORCID: https://orcid.org/0000-0001-6097-1384)
- Yongjian Liu
- Chi Liu
- Saalar Zarnegar
Institutions
- Yale University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-02
- DOI
- https://doi.org/10.64898/2026.01.02.697375
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health