Loss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid Handling
Ube4A is a previously unrecognized regulator of colon homeostasis. Its loss induces existing epithelial stress and metabolic reprogramming that sensitize the colon to exaggerated inflammatory responses during injury such as experimental colitis.
Authors
- Vincenza Cifarelli (ORCID: https://orcid.org/0000-0002-9940-4106)
- Anutosh Chakraborty (ORCID: https://orcid.org/0000-0002-0100-6530)
- E C Ebert (ORCID: https://orcid.org/0009-0000-1293-3180)
- Simon Guignard (ORCID: https://orcid.org/0000-0002-9560-0046)
- Silvia González-Nieves (ORCID: https://orcid.org/0000-0002-4706-6184)
- Ryan M. Teague (ORCID: https://orcid.org/0000-0002-8426-2870)
- David DeBruin (ORCID: https://orcid.org/0009-0009-7644-1367)
- Molee Chakraborty
- Michelle Brennan
- Anastasiia Vinogradskaia
Institutions
- University of Florida (US)
- Saint Louis University (US)
- Florida College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-03
- DOI
- https://doi.org/10.64898/2026.01.02.697430
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Saint Louis University