Profiles and Predictors of Neurodevelopmental Outcome at 5–6 Years in Children With a History of Acute Provoked Neonatal Seizures
Nearly two-thirds of 5 to 6-year-old children with provoked neonatal seizures had typical development. Yet, executive and behavioral dysregulation were prevalent, even with preserved cognitive and physical function. These findings can inform outcome discussions and interventions to promote neurodevelopment. ANN NEUROL 2026;99:777-791.
Authors
- Monica E. Lemmon (ORCID: https://orcid.org/0000-0001-6253-775X)
- Tayyba Anwar (ORCID: https://orcid.org/0000-0002-1686-8352)
- Jennifer C. Gidley Larson
- Janet S. Soul (ORCID: https://orcid.org/0000-0001-6998-7753)
- Julie Sturza (ORCID: https://orcid.org/0009-0006-1486-1890)
- Charles E. McCulloch (ORCID: https://orcid.org/0000-0002-1279-6179)
- Renée A. Shellhaas (ORCID: https://orcid.org/0000-0002-3175-3908)
- Courtney J. Wusthoff (ORCID: https://orcid.org/0000-0002-1882-5567)
- Giulia M. Benedetti (ORCID: https://orcid.org/0000-0002-2917-4026)
- Shavonne L. Massey (ORCID: https://orcid.org/0000-0002-8496-221X)
- Cameron Thomas (ORCID: https://orcid.org/0000-0003-1529-2846)
- Madison M. Berl (ORCID: https://orcid.org/0000-0002-2469-1518)
- Hannah C. Glass (ORCID: https://orcid.org/0000-0002-3879-1966)
- Linda S. Franck (ORCID: https://orcid.org/0000-0003-4291-9181)
- CJ Chu
- Jennifer L. Guerrero
- Adam L. Numis
- Stephanie Rau
- Elizabeth E. Rogers
- Yi Li
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- George Washington University Hospital (US)
- Boston Children's Hospital (US)
- Kennedy Krieger Institute (US)
- Children's Hospital of Philadelphia (US)
- Children's National (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Duke University (US)
- Palo Alto University (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- University of California System (US)
- Massachusetts General Hospital (US)
- Michigan Medicine (US)
- UCSF Benioff Children's Hospital (US)
- San Francisco VA Health Care System (US)
- C. S. Mott Children's Hospital (US)
- University of California Davis Medical Center (US)
- Dana-Farber Brigham Cancer Center (US)
- University of San Francisco (US)
- University of California, Davis (US)
- Stanford University (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1002/ana.78100
- Citations
- 1
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 41.22
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke