Impacts of ketogenic diet intervention on cardiometabolic outcomes in obese, dysglycemic mice
This study demonstrates that, in mice, a high cholesterol KD can improve hepatic steatosis particularly when weight loss is achieved, compared to maintaining the western-style HFD. However, no improvements to insulin secretion and glucose tolerance were observed despite elevated post-glucose GLP-1 levels and long-term diminished requirements for insulin.
Authors
- Erin E. Mulvihill (ORCID: https://orcid.org/0000-0002-3981-0241)
- Natasha A. Trzaskalski
- Nadya M. Morrow
- Arianne Morissette
- Elena Cameron
- My-Anh Nguyen
- Ilka Lorenzen-Schmidt
- Cassandra A. A. Locatelli
Institutions
- University of Ottawa (CA)
- Institute of Infection and Immunity (CA)
- Ottawa University (US)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1186/s12933-025-03046-3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00