Podocyte-specific Translational Profiling In Vivo Uncovers Distinct Patterns in Trpc6-Deficient Podocytes

We show that, despite the absence of overt glomerular pathology, young Trpc6-/- podocytes exhibit distinct transcriptional signatures. These alterations may provide critical insights into whether TRPC6 deficiency confers protective potential or instead predisposes podocytes to maladaptive responses under stress. We further demonstrate that these changes are markedly attenuated in aged mice, indicating that TRPC6 deficiency exerts only a mild impact and that TRPC6 may play a diminished role in the aging podocyte population.

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Publication Details

Journal
Nephrology Dialysis Transplantation
Published
2025-12-12
DOI
https://doi.org/10.1093/ndt/gfaf267
Primary Topic
Renal Diseases and Glomerulopathies
Type
article
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article

Podocyte-specific Translational Profiling In Vivo Uncovers Distinct Patterns in Trpc6-Deficient Podocytes

Simon Bedenbender, Andreas Hofmeister, Joachim Hoyer, Ivica Grgic et al.
Nephrology Dialysis Transplantation
Renal Diseases and Glomerulopathies
article

Podocyte-specific Translational Profiling In Vivo Uncovers Distinct Patterns in Trpc6-Deficient Podocytes

Simon Bedenbender, Andreas Hofmeister, Joachim Hoyer, Ivica Grgic, Philipp Russ, Benjamin D. Humphreys, Thomas Gudermann, H. Meyer, Mathieu Preußner, Alexander Dietrich, Jonas Einloft, Stefanie Weber
article en

Abstract

We show that, despite the absence of overt glomerular pathology, young Trpc6-/- podocytes exhibit distinct transcriptional signatures. These alterations may provide critical insights into whether TRPC6 deficiency confers protective potential or instead predisposes podocytes to maladaptive responses under stress. We further demonstrate that these changes are markedly attenuated in aged mice, indicating that TRPC6 deficiency exerts only a mild impact and that TRPC6 may play a diminished role in the aging podocyte population.

Nephrology Dialysis Transplantation
Goethe University Frankfurt (DE), Philipps University of Marburg (DE), Washington University in St. Louis (US), Universitätsklinikum Gießen und Marburg (DE), Institute of Pharmacology (CZ), Ludwig-Maximilians-Universität München (DE)
Openalex Percentile: Top 29%
Renal Diseases and Glomerulopathies
DOISourceOpenAlex
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Podocyte-specific Translational Profiling In Vivo Uncovers Distinct Patterns in Trpc6-Deficient Podocytes — Simon Bedenbender, Andreas Hofmeister, et al. · Nephrology Dialysis Transplantation (2025) | TGRS Research Map | TGRS