Breast-implant associated unicentric castleman disease: a case report
ALK-negative anaplastic large cell lymphoma is a well-established hematologic complication of prosthetic breast implantation, but other rare conditions should also be considered. We report a case of a 36-year-old female with bilateral retropectoral breast implants since age 20 who presented with fatigue, lower extremity edema, fevers, and a slowly growing left breast mass. Ultrasound of the left breast revealed a 6 × 6 cm left upper quadrant mass. Surgical excision identified pathologic features consistent with hyaline-vascular unicentric Castleman disease (UCD). This is the first case of breast-implant associated UCD, expanding the differential diagnosis for masses associated with prosthetic breast implantation.
Authors
- Joshua D. Brandstadter (ORCID: https://orcid.org/0000-0003-0652-5791)
- Bridget Austin
- Saishravan Shyamsundar (ORCID: https://orcid.org/0000-0002-0160-8910)
- Larissa Borys
- Mateo Sarmiento Bustamante (ORCID: https://orcid.org/0009-0002-6774-2714)
- Gordan Srkalović (ORCID: https://orcid.org/0000-0003-3519-0409)
- Mary Jo Lechowicz (ORCID: https://orcid.org/0000-0003-1997-1950)
- Adam Bagg (ORCID: https://orcid.org/0000-0002-1669-468X)
- Frits van Rhee (ORCID: https://orcid.org/0000-0001-9959-1282)
- Amy Chadburn
- Megan S. Lim
- Daisy Alapat
- David C. Fajgenbaum
Institutions
- Sparrow Health System (US)
- Memorial Sloan Kettering Cancer Center (US)
- Emory University (US)
- Cornell University (US)
- Sparrow Hospital (US)
- Winthrop Rockefeller Foundation (US)
- Weill Cornell Medicine (US)
- Winship Cancer Institute
- University of Pennsylvania (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Current Problems in Cancer Case Reports
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1016/j.cpccr.2026.100404
- Primary Topic
- Breast Implant and Reconstruction
- Type
- article
- Field-Weighted Citation Impact
- 0.00